Article
Identification of novel pleiotropic gene for bone mineral density and lean mass using the cFDR method.
Annals of human genetics - 1 Nov 2021
Tan Li-Jun, Li Xiao-Hua, Li Gai-Gai, Hu Yuan, Chen Xiang-Ding, Deng Hong-Wen
Abstract excerpt
Bone mineral density (BMD) and whole-body lean mass (WBLM) are two important phenotypes of osteoporosis and sarcopenia. Previous studies have shown that BMD and lean mass were phenotypically and genetically correlated. To identify the novel common genetic factors shared between BMD and WBLM, we performed the conditional false discovery rate (cFDR) analysis using summary data of the genome-wide association study...
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