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Article

Pleiotropic genomic variants at 17q21.31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis.

European journal of human genetics : EJHG - 1 Apr 2021

Wei Xin-Tong, Feng Gui-Juan, Zhang Hong, Xu Qian, Ni Jing-Jing, Zhao Min, Yang Xiao-Lin, Tian Qing, Shen Hui, Hai Rong, Deng Hong-Wen, Zhang Lei, Pei Yu-Fang

Abstract excerpt

Osteoporosis and obesity are two severe complex diseases threatening public health worldwide. Both diseases are under strong genetic determinants as well as genetically correlated. Aiming to identify pleiotropic genes underlying obesity and osteoporosis, we performed a bivariate genome-wide association (GWA) meta-analysis of hip bone mineral density (BMD) and total body fat mass (TBFM) in 12,981 participants from...

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Bone Density
Chromosomes, Human, Pair 17
Complement C1q
DNA Repair Enzymes
Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing Factors

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Identifiers

PMID: 32963334
DOI: 10.1038/s41431-020-00727-3
PMCID: PMC8115667

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