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Article

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

Human genetics - 1 Aug 2020

Liu Lu, Yang Xiao-Lin, Zhang Hong, Zhang Zi-Jia, Wei Xin-Tong, Feng Gui-Juan, Liu Ju, Peng Hui-Ping, Hai Rong, Shen Hui, Tian Qing, Deng Hong-Wen, Pei Yu-Fang, Zhang Lei

Abstract excerpt

Aiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we performed a bivariate GWAS meta-analysis of femoral neck BMD (FNK-BMD) and trunk fat mass adjusted by trunk lean mass (TFMadj) in 11,496 subjects from 6 samples, followed by in silico replication in the large-scale UK Biobank (UKB) cohort. A series of functional investigations were conducted on the identified variants. Bivariate...

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Share to Body Mass Index
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-gamma

Share to Mendelian Randomization Analysis

Share to Obesity, Abdominal

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Identifiers

PMID: 32239398
DOI: 10.1007/s00439-020-02155-1
PMCID: PMC7883472

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