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Article

MAPK activation drives male and female mouse teratocarcinomas from late primordial germ cells

17 Mar 2022

Abstract excerpt

Germ cell tumors (GCTs) are rare tumors that can develop in both sexes, peaking in adolescents. To understand the mechanisms that underlie germ cell transformation, we established a GCT mouse model carrying a germ-cell-specific BRafV600E mutation with or without heterozygous Pten deletion. Both male and female mice developed monolateral teratocarcinomas containing embryonal carcinoma (EC) cells that showed an...

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PMID: 35297490
DOI: 10.1242/jcs.259375

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