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Article

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

5 Mar 2003

Abstract excerpt

The tumor suppressor gene PTEN, which is frequently mutated in human cancers, encodes a lipid phosphatase for phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3] and antagonizes phosphatidylinositol 3 kinase. Primordial germ cells (PGCs), which are the embryonic precursors of gametes, are the source of testicular teratoma. To elucidate the intracellular signaling mechanisms that underlie germ cell...

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PMID: 12620992
DOI: 10.1242/dev.00392

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