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Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence

6 May 2023

Abstract excerpt

Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In contrast, pre-pubertal (type I) GCTs are limited to (benign) teratoma and (malignant) yolk sac tumor (YST). Epidemiologic and molecular data have shown that pre- and...

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PMID: 37149691
DOI: 10.1038/s41467-023-38378-9

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