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Article

The plasticity of germ cell cancers and its dependence on the cellular microenvironment

28 Feb 2017

Abstract excerpt

So far, the understanding of germ cell cancer (GCC) pathogenesis is based on a model, where seminomas and non-seminomas represent distinct entities although originating from a common precursor termed germ cell neoplasia in situ (GCNIS). Embryonal carcinomas (ECs), the stem cell population of the non-seminomas, is pluri- to totipotent and able to differentiate into cells of all three germ layers, giving rise to...

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PMID: 28244655
DOI: 10.1111/jcmm.13082

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