Article

FGF independent MEK1/2 signalling is essential for male fetal germline development in mice

2023-02-08

Abstract excerpt

<h4>Background</h4> Germline development provides the founding cells for spermatogenesis and oogenesis in males and females, respectively. Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of a range of genes, including Fgf9, that promote Sertoli cell differ...

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Literature Corpus work: 5067aec9-ec58-56b3-9eb9-827153196a3f
DOI: 10.1101/2023.02.05.527224

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