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Recent Advances in Understanding the Etiology and Pathogenesis of Pediatric Germ Cell Tumors

27 Feb 2014

Abstract excerpt

Pediatric germ cell tumors (GCTs) are rare neoplasms arising predominantly in the gonads and sacrococcygeal, mediastinal, and intracranial localizations. In this article, we review current knowledge of pathogenesis of pediatric GCTs, which differs from adult/adolescent GCTs. One distinctive feature is the absence of a progenitor stage, such as carcinoma in situ or gonadoblastoma, which are seen in...

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PMID: 24577549
DOI: 10.1097/mph.0000000000000125

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