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Article

Akt/PTEN Signaling Mediates Estrogen-Dependent Proliferation of Primordial Germ Cells<i>in Vitro</i>

7 Oct 2003

Abstract excerpt

Testicular tumors in humans are reported to be significantly increasing in incidence. Embryo exposure to environmental estrogens has been proposed as one of the possible underlying causes. In mice, genetic, immunological, and experimental evidence suggest that germ cell testicular tumors may derive from primordial germ cells (PGCs), the embryonic precursors of gametes. Here we show that relatively high...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 14525951
DOI: 10.1210/me.2003-0006

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Akt/PTEN Signaling Mediates Estrogen-Dependent Proliferation of Primordial Germ Cells<i>in Vitro</i>PMID 14525951Read ↗

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