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DNA replication fork speed underlies cell fate changes and promotes reprogramming

1 Mar 2022

Abstract excerpt

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into totipotent-like 2-cell-like cells (2CLCs). We show that totipotent cells of the early mouse embryo have slow DNA replication fork speed and that 2CLCs recapitulate this feature, suggesting that...

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PMID: 35256805
DOI: 10.1038/s41588-022-01023-0

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