Article

Physiological re-replication during human stem cell differentiation

2026-02-27

Abstract excerpt

During defined developmental windows in Drosophila, controlled re-replication generates physiological gene amplification. Although gene amplification has also been observed during human stem cell differentiation, re-replication in human cells has largely been linked to tumor-associated genome instability. Here, we demonstrate that re-replication likewise operates as a physiological mechanism in human stem cells. U...

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Literature Corpus work: 30db6589-64d7-54fd-85f6-eeea7e8d2688
DOI: 10.64898/2026.02.27.708451

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