Article

A probabilistic framework for cellular lineage reconstruction using single-cell 5-hydroxymethylcytosine sequencing

2019-08-19

Abstract excerpt

Lineage reconstruction is central to understanding tissue development and maintenance. While powerful tools to infer cellular relationships have been developed, these methods typically have a clonal resolution that prevent the reconstruction of lineage trees at an individual cell division resolution. Moreover, these methods require a transgene, which poses a significant barrier in the study of human tissues. To ov...

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Literature Corpus work: 8341708d-67bb-5fde-a826-ef2d06bc8ea4
DOI: 10.1101/739300

Open publication

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