Article

DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility

2023-12-26

Abstract excerpt

DNA replication in differentiated cells follows a defined program, but when and how it is established during mammalian development is not known. Here we show using single-cell sequencing, that both bovine and mouse cleavage stage embryos progress through S-phase in a defined pattern. Late replicating regions are associated with the nuclear lamina from the first cell cycle after fertilization, and contain few activ...

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Identifiers and source

Literature Corpus work: c3afa237-48de-56d9-a543-cee16e54ca83
DOI: 10.1101/2023.12.25.573304

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