Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific Components

16 Feb 2022

Abstract excerpt

INTRODUCTION AND OBJECTIVES: Genome-wide association studies have identified a high number of genetic loci associated with hypertension suggesting the presence of an underlying polygenic architecture. In this study, we aimed to dissect the polygenic component of primary hypertension searching also for pathway-specific components. METHODS: The polygenic risk score (PRS) models, based on the UK biobank genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Nutrition, Genetics, and Disease
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35252394
DOI: 10.3389/fcvm.2022.814502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific ComponentsPMID 35252394Read ↗

Recessive and sex-dependent genetic effects in primary hypertensionSemantic proximity Read ↗

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Semantic proximity Read ↗

Polygenic risk score and clinical factors predict incident idiopathic pulmonary arterial hypertension.Semantic proximity Read ↗

Genetic basis of polygenic hypertensionSemantic proximity Read ↗

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African CohortSemantic proximity Read ↗

An integrated polygenic score stratifies risk of peripheral artery disease and adverse limb events in ancestrally diverse cohortsSemantic proximity Read ↗

Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics.Semantic proximity Read ↗

The power of pathway-based polygenic risk scoresSemantic proximity Read ↗

Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicatedSemantic proximity Read ↗

Polygenic Risk Score: Clinically Useful Tool for Prediction of Cardiovascular Disease and Benefit from Lipid-Lowering Therapy?Semantic proximity Read ↗

Blood Pressure Genetics in Han Taiwanese With Cross-Trait Analysis in East Asians: Insights Into Comorbidities, All-Cause Mortality, and Cardiovascular MortalitySemantic proximity Read ↗

Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.