An integrated polygenic score stratifies risk of peripheral artery disease and adverse limb events in ancestrally diverse cohorts

Abstract excerpt

<h4>Background and Aims</h4> Peripheral artery disease (PAD) is a heritable atherosclerotic condition that is underdiagnosed and undertreated. With growing knowledge of the genetic basis for PAD and related risk factors, this study sought to construct a new polygenic score for PAD (GPS PAD ). <h4>Methods</h4> GPS PAD was constructed by integrating multi-ancestry summary statistics for PAD and related traits. GPS P...

Topics

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• Coronary Artery Disease
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Multifactorial Inheritance
• Peripheral Arterial Disease
• Phenotype
• Risk Assessment
• Risk Factors

Identifiers and source

Literature Corpus work

99e88e8f-22ac-5f86-a91e-7ee93aea9349

DOI

10.1101/2024.10.04.24314847