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Polygenic Risk Score: Clinically Useful Tool for Prediction of Cardiovascular Disease and Benefit from Lipid-Lowering Therapy?

Cardiovascular drugs and therapy - 1 Jun 2021

Arnold Natalie, Koenig Wolfgang

Abstract excerpt

Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using information on the genetic predisposition at an individual level might offer new possibilities for the successful management of such complex trait. Latest developments in genetic research with the conduction of genome-wide association studies have facilitated a broader utility of polygenic risk score (PRS) as a potent risk...

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PMID: 33156471
DOI: 10.1007/s10557-020-07105-7
PMCID: PMC8481165

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