Article

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African Cohort

2025-07-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Genome-wide polygenic risk scores (PRS) are useful for stratifying individuals’ risk for polygenic diseases such as hypertension. However, a downside of genome-wide PRS is the lack of information about the distribution of risk burden across biologic pathways. We used pathway-specific PRS to investigate these effects within common anti-hypertensive therapy-target pathways on...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24b3a28c-900c-5499-902b-6b03f979f0c6
DOI: 10.1101/2025.06.30.25330577

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African CohortDOI 10.1101/2025.06.30.25330577Read

Recessive and sex-dependent genetic effects in primary hypertensionSemantic proximity Read

Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular EventsSemantic proximity Read

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Semantic proximity Read

Meta-analysis and Multivariate GWAS Analyses in 77,850 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure TraitsSemantic proximity Read

Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressureSemantic proximity Read

Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific ComponentsSemantic proximity Read

Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk.Semantic proximity Read

The power of pathway-based polygenic risk scoresSemantic proximity Read

Polygenic risk scores associate with blood pressure traits across the lifespan.Semantic proximity Read

Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African AmericansSemantic proximity Read

Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank.Semantic proximity Read

Polygenic prediction of lipid traits in sub-Saharan AfricansSemantic proximity Read