Article
Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes.
Pharmacogenetics and genomics - 1 Jun 2022
Langlois Alec W R, El-Boraie Ahmed, Fukunaga Koya, Mushiroda Taisei, Kubo Michiaki, Lerman Caryn, Knight Jo, Scherer Steven E, Chenoweth Meghan J, Tyndale Rachel F
Abstract excerpt
OBJECTIVES: We evaluated multiple genotyping/sequencing approaches in a homologous region of chromosome 19, and investigated associations of two common 3'-UTR CYP2A6 variants with activity in vivo. METHODS: Individuals (n = 1704) of European and African ancestry were phenotyped for the nicotine metabolite ratio (NMR), an index of CYP2A6 activity, and genotyped/sequenced using deep amplicon exon sequencing, SNP...
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