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Article

Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension.

European journal of human genetics : EJHG - 1 Mar 2024

Langlois Alec W R, Pouget Jennie G, Knight Jo, Chenoweth Meghan J, Tyndale Rachel F

Abstract excerpt

CYP2A6 is a polymorphic enzyme that inactivates nicotine; structural variants (SVs) include gene deletions and hybrids with the neighboring pseudogene CYP2A7. Two studies found that CYP2A7 deletions were associated with ovarian cancer risk. Using their methodology, we aimed to characterize CYP2A6 SVs (which may be misidentified by prediction software as CYP2A7 SVs), then assess CYP2A6 SV-associated risk for...

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Source

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Identifiers

PMID: 38097766
DOI: 10.1038/s41431-023-01518-2
PMCID: PMC10923790

Genes

CYP2A6
CYP2A7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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