Article
Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.
PloS one - 1 Jan 2015
Bergen Andrew W, Michel Martha, Nishita Denise, Krasnow Ruth, Javitz Harold S, Conneely Karen N, Lessov-Schlaggar Christina N, Hops Hyman, Zhu Andy Z X, Baurley James W, McClure Jennifer B, Hall Sharon M, Baker Timothy B, Conti David V, Benowitz Neal L, Lerman Caryn, Tyndale Rachel F, Swan Gary E
Abstract excerpt
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme and transporter (DMET) gene variation associated with the NMR and prospective abstinence in 2,946 participants of laboratory studies of nicotine metabolism and of...
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