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Article

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

Addiction (Abingdon, England) - 1 Mar 2018

Chenoweth Meghan J, Ware Jennifer J, Zhu Andy Z X, Cole Christopher B, Cox Lisa Sanderson, Nollen Nikki, Ahluwalia Jasjit S, Benowitz Neal L, Schnoll Robert A, Hawk Larry W, Cinciripini Paul M, George Tony P, Lerman Caryn, Knight Joanne, Tyndale Rachel F

Abstract excerpt

BACKGROUND AND AIMS: The activity of CYP2A6, the major nicotine-inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associated with smoking behaviours and response to pharmacotherapies. The NMR is highly heritable (~80%), and on average lower in African Americans (AA) versus whites. We previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28921760
DOI: 10.1111/add.14032
PMCID: PMC5807179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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