Article
Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.
Cancer immunology research - 1 Apr 2022
Mujal Adriana M, Combes Alexis J, Rao Arjun A, Binnewies Mikhail, Samad Bushra, Tsui Jessica, Boissonnas Alexandre, Pollack Joshua L, Argüello Rafael J, Meng Maxwell V, Porten Sima P, Ruhland Megan K, Barry Kevin C, Chan Vincent, Krummel Matthew F
Abstract excerpt
The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determine their connections to T-cell function and their relationship to patient outcome. Here, we have leveraged single-cell RNA-sequencing analysis of several mouse and human tumors and...
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