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Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies.

Trends in immunology - 1 Dec 2023

Nasir Ibraheem, McGuinness Conor, Poh Ashleigh R, Ernst Matthias, Darcy Phillip K, Britt Kara L

Abstract excerpt

Macrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging...

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PMID: 37995659
DOI: 10.1016/j.it.2023.10.007

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