Article

The immune landscape of tumor-associated macrophage reprogramming

2024-09-27

Abstract excerpt

<h4>Summary</h4> Tumor-associated macrophages (TAMs) generally acquire immunosuppressive and tumor-promoting phenotypes, which may contribute to tumor resistance to immunotherapy. We previously showed that suppression of microRNA activity through genetic Dicer1 inactivation rewires TAM’s transcriptomes and prompts their immunostimulatory activation. This phenotypic switch enhanced recruitment and activation of C...

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Literature Corpus work: 37214c88-cd92-58cb-936a-c99ccdd1ebf7
DOI: 10.1101/2024.09.25.614962

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