Article

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

2021-07-08

Abstract excerpt

The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid cell identity and plasticity has challenged efforts to define bona fide populations and determine their connections to T cell function and their relation to patient outcome. Here we leverage single-cell RNA-sequencing (scRNA-seq) analysis of several mouse and human tumors and fi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 996da038-8566-5bcc-ac4e-e57b26c4160a
DOI: 10.1101/2021.07.07.451502

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney CancerDOI 10.1101/2021.07.07.451502Read

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.Semantic proximity Read

Monocytes and Macrophages in Kidney Transplantation and Insights from Single Cell RNA-Seq StudiesSemantic proximity Read

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.Semantic proximity Read

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritisSemantic proximity Read

Tumor-associated macrophage clusters linked to immunotherapy in a pan-cancer censusSemantic proximity Read

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney DiseaseSemantic proximity Read

Mapping the immune environment in clear cell renal carcinoma by single-cell genomicsSemantic proximity Read

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney diseaseSemantic proximity Read

Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in GliomasSemantic proximity Read

Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies.Semantic proximity Read

Hierarchical classification of immune cell transcriptomes at population-scaleSemantic proximity Read

Distinct Tumor-Associated Macrophage Signatures Shape the Immune Microenvironment and Patient Prognosis in Renal Cell CarcinomaSemantic proximity Read