Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint.

Current genetics - 1 Apr 2022

Gasparayan Hovik, Caridi Chris, Julius Jeff, Feng Wenyi, Bachant Jeff, Nugent Constance I

Abstract excerpt

Treating yeast cells with the replication inhibitor hydroxyurea activates the S phase checkpoint kinase Rad53, eliciting responses that block DNA replication origin firing, stabilize replication forks, and prevent premature extension of the mitotic spindle. We previously found overproduction of Stn1, a subunit of the telomere-binding Cdc13-Stn1-Ten1 complex, circumvents Rad53 checkpoint functions in hydroxyurea,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Checkpoint Kinase 2
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Serine-Threonine Kinases

Share to S Phase

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 35150303
DOI: 10.1007/s00294-022-01228-0
PMCID: PMC8976814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint.PMID 35150303Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.Semantic proximity Read ↗

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication RestartSemantic proximity Read ↗

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication StressSemantic proximity Read ↗

Elevated Levels of Mcm7 Disrupt Microtubule and Nucleolar Homeostasis to Drive Genome Instability and Cell DeathSemantic proximity Read ↗

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.Semantic proximity Read ↗

Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.Semantic proximity Read ↗

Cdc13 both positively and negatively regulates telomere replication.Semantic proximity Read ↗

Human CST complex restricts excessive PrimPol repriming upon UV induced replication stress by suppressing p21Semantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.