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Article

Cdc13 both positively and negatively regulates telomere replication.

Genes & development - 15 Feb 2001

Chandra A, Hughes T R, Nugent C I, Lundblad V

Abstract excerpt

Cdc13 is a single-strand telomeric DNA-binding protein that positively regulates yeast telomere replication by recruiting telomerase to chromosome termini through a site on Cdc13 that is eliminated by the cdc13-2 mutation. Here we show that Cdc13 has a separate role in negative regulation of telomere replication, based on analysis of a new mutation, cdc13-5. Loss of this second regulatory activity results in...

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Identifiers

PMID: 11230149
DOI: 10.1101/gad.861001
PMCID: PMC312634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cdc13 both positively and negatively regulates telomere replication.PMID 11230149Read ↗

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.Semantic proximity Read ↗

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.Semantic proximity Read ↗

New function of CDC13 in positive telomere length regulation.Semantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.Semantic proximity Read ↗

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance.Semantic proximity Read ↗

The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p.Semantic proximity Read ↗

Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.Semantic proximity Read ↗

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Semantic proximity Read ↗

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.Semantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

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