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Article

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication Restart

12 Sept 2013

Abstract excerpt

TEN1 is a component of the mammalian CTC1-STN1-TEN1 complex. CTC1 and/or STN1 functions in telomere duplex replication, C-strand fill-in, and genome-wide restart of replication following fork stalling. Here we examine the role of human TEN1 and ask whether it also functions as a specialized replication factor. TEN1 depletion causes an increase in multitelomere fluorescent in situ hybridization (FISH) signals...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 24025336
DOI: 10.1074/jbc.m113.493478

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