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Article

Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.

Molecular biology of the cell - 1 Aug 2007

Ma Lina, McQueen Jennifer, Cuschieri Lara, Vogel Jackie, Measday Vivien

Abstract excerpt

The kinetochore, a protein complex that links chromosomes to microtubules (MTs), is required to prevent spindle expansion during S phase in budding yeast, but the mechanism of how the kinetochore maintains integrity of the bipolar spindle before mitosis is not well understood. Here, we demonstrate that a mutation of Spc24, a component of the conserved Ndc80 kinetochore complex, causes lethality when cells are...

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Identifiers

PMID: 17507656
DOI: 10.1091/mbc.e06-09-0882
PMCID: PMC1949354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.PMID 17507656Read ↗

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Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle.Semantic proximity Read ↗

Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint.Semantic proximity Read ↗

The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Semantic proximity Read ↗

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Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest.Semantic proximity Read ↗

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