Article
TEN1 is essential for CDC13-mediated telomere capping.
Genetics - 1 Nov 2009
Xu Ling, Petreaca Ruben C, Gasparyan Hovik J, Vu Stephanie, Nugent Constance I
Abstract excerpt
Telomere binding proteins protect chromosome ends from degradation and mask chromosome termini from checkpoint surveillance. In Saccharomyces cerevisiae, Cdc13 binds single-stranded G-rich telomere repeats, maintaining telomere integrity and length. Two additional proteins, Ten1 and Stn1, interact with Cdc13 but their contributions to telomere integrity are not well defined. Ten1 is known to prevent accumulation...
Topics
- Blotting, Western
- Cell Division
- Chromatin Immunoprecipitation
- Chromosomal Proteins, Non-Histone
- DNA Polymerase I
- DNA Repair
- DNA, Single-Stranded
- Exodeoxyribonucleases
- G2 Phase
- Mutation
- Protein Binding
- Rad52 DNA Repair and Recombination Protein
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins