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Human CST complex restricts excessive PrimPol repriming upon UV induced replication stress by suppressing p21

13 Feb 2024

Abstract excerpt

DNA replication stress, caused by various endogenous and exogenous agents, halt or stall DNA replication progression. Cells have developed diverse mechanisms to tolerate and overcome replication stress, enabling them to continue replication. One effective strategy to overcome stalled replication involves skipping the DNA lesion using a specialized polymerase known as PrimPol, which reinitiates DNA synthesis...

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PMID: 38348929
DOI: 10.1093/nar/gkae078

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