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Article

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.

The EMBO journal - 1 Mar 2001

Grandin N, Damon C, Charbonneau M

Abstract excerpt

In Saccharomyces cerevisiae, Cdc13 has been proposed to mediate telomerase recruitment at telomere ends. Stn1, which associates with Cdc13 by the two-hybrid interaction, has been implicated in telomere maintenance. Ten1, a previously uncharacterized protein, was found to associate physically with both Stn1 and Cdc13. A binding defect between Stn1-13 and Ten1 was responsible for the long telomere phenotype of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11230140
DOI: 10.1093/emboj/20.5.1173
PMCID: PMC145504

Genes

TEN1
STN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.PMID 11230140Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Semantic proximity Read ↗

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.Semantic proximity Read ↗

The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p.Semantic proximity Read ↗

Dysfunction of Telomeric Cdc13-Stn1-Ten1 Simultaneously Activates DNA Damage and Spindle Checkpoints.Semantic proximity Read ↗

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.Semantic proximity Read ↗

Cdc13 both positively and negatively regulates telomere replication.Semantic proximity Read ↗

MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Semantic proximity Read ↗

Protection of telomeres by a conserved Stn1–Ten1 complexSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Semantic proximity Read ↗

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