Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.

doi:10.1093/emboj/20.21.6127

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Article

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.

The EMBO journal - 1 Nov 2001

Grandin N, Damon C, Charbonneau M

Abstract excerpt

Cdc13 performs an essential function in telomere end protection in budding yeast. Here, we analyze the consequences on telomere dynamics of cdc13-induced telomeric DNA damage in proliferating cells. Checkpoint-deficient cdc13-1 cells accumulated DNA damage and eventually senesced. However, these telomerase-proficient cells could survive by using homologous recombination but, contrary to telomerase-deficient...

Topics

Cell Cycle Proteins
Cell Survival
Cellular Senescence
Cyclin B
DNA Damage
DNA-Binding Proteins
Fungal Proteins
Genes, cdc
Mutation
Rad51 Recombinase
Rad52 DNA Repair and Recombination Protein
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Telomerase
Telomere
Telomere-Binding Proteins
Temperature

Source

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Identifiers

PMID: 11689452
DOI: 10.1093/emboj/20.21.6127
PMCID: PMC125707

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