Article
Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.
Current psychiatry reports - 1 Apr 2011
Sherva Richard, Farrer Lindsay A
Abstract excerpt
Until recently, the search for genes contributing to Alzheimer's disease (AD) had been slow and disappointing, with the notable exception of the APOE ε4 allele, which increases risk and reduces the age at onset of AD in a dose-dependent fashion. Findings from genome-wide association studies (GWAS) made up of fewer than several thousand cases and controls each have not been replicated. Efforts of several...
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