Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer

1 Feb 2022

Abstract excerpt

Distinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation of these stem cells through the regulation of their self-renewal and terminal differentiation; however, the underlying mechanistic role regulated by ∆Np63 in lung cancer development has remained elusive. By utilizing a ΔNp63-specific conditional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35105868
DOI: 10.1038/s41467-022-28202-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancerPMID 35105868Read ↗

Marker-based CRISPR screens identify POU2F1 as a regulator of DLL3 and neuroendocrine identity in small cell lung cancerSemantic proximity Read ↗

Transcriptional Circuitry of NKX2-1 and SOX1 Defines an Unrecognized Lineage Subtype of Small-Cell Lung CancerSemantic proximity Read ↗

p53 governs an AT1 differentiation programme in lung cancer suppression.Semantic proximity Read ↗

ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancerSemantic proximity Read ↗

POU2AF2/C11orf53 functions as a co-activator of POU2F3 by maintaining chromatin accessibility and enhancer activitySemantic proximity Read ↗

ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of originSemantic proximity Read ↗

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.Semantic proximity Read ↗

Distinct interactors define the p63 transcriptional signature in epithelial development or cancerSemantic proximity Read ↗

Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas.Semantic proximity Read ↗

The USP28-ΔNp63 axis is a vulnerability of squamous tumoursSemantic proximity Read ↗

XPC restrains cancer stemness by modulating STAT1-SOX2 signaling in non-small cell lung cancerSemantic proximity Read ↗

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.