Article

The USP28-ΔNp63 axis is a vulnerability of squamous tumours

2019-06-27

Abstract excerpt

The transcription factor ΔNp63 is a master regulator that establishes epithelial cell identity and is essential for the survival of SCC of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase USP28 stabilizes ΔNp63 protein and maintains elevated ΔNP63 levels in SCC by counteracting its proteasome-mediated degradation. Interference with USP28 activity by genetic means abolishes...

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Literature Corpus work: ad098f67-355c-5f89-8eb4-18f6771541bf
DOI: 10.1101/683508

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