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Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

4 Mar 2020

Abstract excerpt

The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase USP28 stabilizes ∆Np63 and maintains elevated ∆NP63 levels in SCC by counteracting its proteasome-mediated degradation. Impaired USP28 activity, either genetically or...

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PMID: 32128997
DOI: 10.15252/emmm.201911101

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