Article

ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of origin

2020-11-11

Abstract excerpt

ASCL1 is a neuroendocrine-lineage-specific oncogenic driver of small cell lung cancer (SCLC), highly expressed in a significant fraction of tumors. However, ~25% of human SCLC are ASCL1-low and associated with low-neuroendocrine fate and high MYC expression. Using genetically-engineered mouse models (GEMMs), we show that alterations in Rb1/Trp53/Myc in the mouse lung induce an ASCL1 + state of SCLC in multiple c...

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Literature Corpus work: 95ef57d4-0810-5255-be18-fe09b748453e
DOI: 10.1101/2020.11.11.362632

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