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Article

Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas.

Nature genetics - 1 Dec 2025

Panja Sukanya, Mantri Padmaja, Johnson Kofi Ennu, Andrade-Martinez Juan Sebastian, Yang Soo-Ryum, Deshpande Aditya, Tian Huasong, Beg Shaham, Ohara Kentaro, Leal Alessandro, Rosiene Joel, Stoeckius Marlon, Smibert Peter, Travis William D, Mosquera Juan Miguel, Polak Paz, Imieliński Marcin

Abstract excerpt

DNA damage is preferentially repaired in expressed genes; thus, genome-wide correlations between somatic mutation patterns and normal cell transcription may reflect tumor cell origins. Accordingly, we found that aggregate lung adenocarcinoma (LUAD) and squamous cancer (LUSC) somatic mutation density associated most strongly with distal (alveolar) and proximal (basal) lung cell-type-specific gene expression,...

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Identifiers

PMID: 41310231
DOI: 10.1038/s41588-025-02418-5
PMCID: PMC13425454

Genes

EGFR
KRAS
SMARCA4
STK11
TP53

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