Article
Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells.
Science (New York, N.Y.) - 10 Jan 2014
Deng Qiaolin, Ramsköld Daniel, Reinius Björn, Sandberg Rickard
Abstract excerpt
Expression from both alleles is generally observed in analyses of diploid cell populations, but studies addressing allelic expression patterns genome-wide in single cells are lacking. Here, we present global analyses of allelic expression across individual cells of mouse preimplantation embryos of mixed background (CAST/EiJ × C57BL/6J). We discovered abundant (12 to 24%) monoallelic expression of autosomal genes...
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