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Article

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex.

Scientific reports - 27 Jan 2022

Sethumadhavan Sunesh, Barth Marie, Spaapen Robbert M, Schmidt Carla, Trowitzsch Simon, Tampé Robert

Abstract excerpt

Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. The transporter associated with antigen processing (TAP) shuttles proteasomally generated peptides into the ER for MHC I loading. As central part of the peptide-loading complex (PLC), TAP is targeted by viral factors, which inhibit peptide supply and thereby impact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35087068
DOI: 10.1038/s41598-022-05000-9
PMCID: PMC8795405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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