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Article

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.

Molecular immunology - 1 Sept 2018

Praest P, Luteijn R D, Brak-Boer I G J, Lanfermeijer J, Hoelen H, Ijgosse L, Costa A I, Gorham R D, Lebbink R J, Wiertz E J H J

Abstract excerpt

Herpesviruses encode numerous immune evasion molecules that interfere with the immune system, particularly with certain stages in the MHC class I antigen presentation pathway. In this pathway, the transporter associated with antigen processing (TAP) is a frequent target of viral immune evasion strategies. This ER-resident transporter is composed of the proteins TAP1 and TAP2, and plays a crucial role in the...

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Share to Antibodies, Monoclonal
Share to ATP Binding Cassette Transporter, Subfamily B, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HEK293 Cells

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Source

Identifiers

PMID: 29879547
DOI: 10.1016/j.molimm.2018.05.025

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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