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Structure of the transporter associated with antigen processing trapped by herpes simplex virus

9 Dec 2016

Abstract excerpt

The transporter associated with antigen processing (TAP) is an ATP-binding cassette (ABC) transporter essential to cellular immunity against viral infection. Some persistent viruses have evolved strategies to inhibit TAP so that they may go undetected by the immune system. The herpes simplex virus for example evades immune surveillance by blocking peptide transport with a small viral protein ICP47. In this study,...

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PMID: 27935481
DOI: 10.7554/elife.21829

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