Article
Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning.
eLife - 20 Jun 2024
Gerke Carolin, Bauersfeld Liane, Schirmeister Ivo, Mireisz Chiara Noemi-Marie, Oberhardt Valerie, Mery Lea, Wu Di, Jürges Christopher Sebastian, Spaapen Robbert M, Mussolino Claudio, Le-Trilling Vu Thuy Khanh, Trilling Mirko, Dölken Lars, Paster Wolfgang, Erhard Florian, Hofmann Maike, Schlosser Andreas, Hengel Hartmut, Momburg Frank, Halenius Anne
Abstract excerpt
Human leucocyte antigen class I (HLA-I) molecules play a central role for both NK and T-cell responses that prevent serious human cytomegalovirus (HCMV) disease. To create opportunities for viral spread, several HCMV-encoded immunoevasins employ diverse strategies to target HLA-I. Among these, the glycoprotein US10 is so far insufficiently studied. While it was reported that US10 interferes with HLA-G expression,...
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