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Article

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.

Cell - 20 May 1994

York I A, Roop C, Andrews D W, Riddell S R, Graham F L, Johnson D C

Abstract excerpt

Herpes simplex virus (HSV) infection of human fibroblasts rapidly renders the cells resistant to lysis by HSV-specific CD8+ cytotoxic T lymphocytes (CTLs), which normally recognize cell surface major histocompatibility complex (MHC) class I proteins presenting viral peptides. Within 3 hr of infection with HSV, MHC class I protein complexes are retained in the endoplasmic reticulum (ER)/cis Golgi and show...

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Identifiers

PMID: 8187174
DOI: 10.1016/0092-8674(94)90215-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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