Article
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.
Cell - 20 May 1994
York I A, Roop C, Andrews D W, Riddell S R, Graham F L, Johnson D C
Abstract excerpt
Herpes simplex virus (HSV) infection of human fibroblasts rapidly renders the cells resistant to lysis by HSV-specific CD8+ cytotoxic T lymphocytes (CTLs), which normally recognize cell surface major histocompatibility complex (MHC) class I proteins presenting viral peptides. Within 3 hr of infec...
Topics
- Amino Acid Sequence
- Animals
- Antigen Presentation
- CD8 Antigens
- Cell Line
- Cell Nucleus
- Cytoplasm
- Cytotoxicity, Immunologic
- Endoplasmic Reticulum
- Fibroblasts
- Gene Expression
- Histocompatibility Antigens Class I
- Humans
- Immediate-Early Proteins
- Molecular Sequence Data
- Mutation
- Protein Folding
- Recombinant Proteins