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Simplexviruses Successfully Adapt to Their Host by Fine-Tuning Immune Responses

22 Jun 2022

Abstract excerpt

Primate herpes simplex viruses are species-specific and relatively harmless to their natural hosts. However, cross-species transmission is often associated with severe disease, as exemplified by the virulence of macacine herpesvirus 1 (B virus) in humans. We performed a genome-wide scan for signals of adaptation of simplexviruses to their hominin hosts. Among core genes, we found evidence of episodic positive...

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PMID: 35731846
DOI: 10.1093/molbev/msac142

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