Article

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

2023-01-13

Abstract excerpt

To control human cytomegalovirus (HCMV) infection, NK cells and CD8 + T-cells are crucial. HLA class I (HLA-I) molecules play a central role for both NK and T-cell responses and are targets of multifaceted HCMV-encoded immunoevasins. A so far insufficiently studied HLA-I immunoevasin is the glycoprotein US10. It was shown that US10 targets HLA-G, but it is unknown whether US10 contributes also to escape from clas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11bacac4-a9c2-527c-9b62-d7c5155a841e
DOI: 10.1101/2023.01.10.523457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterningDOI 10.1101/2023.01.10.523457Read

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning.Semantic proximity Read

NK Cell Activity During Human Cytomegalovirus Infection Is Dominated by US2–11-Mediated HLA Class I Down-RegulationSemantic proximity Read

The Human Cytomegalovirus US10 Gene Product Delays Trafficking of Major Histocompatibility Complex Class I MoleculesSemantic proximity Read

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex.Semantic proximity Read

Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.Semantic proximity Read

Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11‐mediated down‐regulationSemantic proximity Read

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the CytosolSemantic proximity Read

CD8 T cell-evasive functions of human cytomegalovirus display pervasive MHC allele specificity, complementarity, and cooperativity.Semantic proximity Read

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activationSemantic proximity Read

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus ImmunoevasionSemantic proximity Read

Ex Vivo Profiling of CD8<sup>+</sup>-T-Cell Responses to Human Cytomegalovirus Reveals Broad and Multispecific Reactivities in Healthy Virus CarriersSemantic proximity Read

Human cytomegalovirus US3 modulates destruction of MHC class I moleculesSemantic proximity Read