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Article

Understanding the assumptions underlying Mendelian randomization.

European journal of human genetics : EJHG - 1 Jun 2022

de Leeuw Christiaan, Savage Jeanne, Bucur Ioan Gabriel, Heskes Tom, Posthuma Danielle

Abstract excerpt

With the rapidly increasing availability of large genetic data sets in recent years, Mendelian Randomization (MR) has quickly gained popularity as a novel secondary analysis method. Leveraging genetic variants as instrumental variables, MR can be used to estimate the causal effects of one phenotype on another even when experimental research is not feasible, and therefore has the potential to be highly...

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Identifiers

PMID: 35082398
DOI: 10.1038/s41431-022-01038-5
PMCID: PMC9177700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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