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Article

Mendelian randomization: genetic anchors for causal inference in epidemiological studies.

Human molecular genetics - 15 Sept 2014

Davey Smith George, Hemani Gibran

Abstract excerpt

Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of the causal effects of modifiable exposures on disease outcomes. Mendelian randomization (MR) is a method that utilizes genetic variants that are robustly associated with such modifiable exposures to generate more reliable evidence...

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Identifiers

PMID: 25064373
DOI: 10.1093/hmg/ddu328
PMCID: PMC4170722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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